Protein Details: Potassium voltage-gated channel subfamily E regulatory beta subunit 5

Protein ID

ICDB_Pro_1666

Protein Name

Potassium voltage-gated channel subfamily E regulatory beta subunit 5

Gene Name

KCNE5; AMMECR2; KCNE1L

Organism

Homo sapiens (Human)

Length

142 amino acids

AlphaFoldDB

AF-Q9UJ90-F1-model_v4.pdb

Function

Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1

Sequence

MNCSESQRLRTLLSRLLLELHHRGNASGLGAGPRPSMGMGVVPDPFVGREVTSAKGDDAYLYILLIMIFYACLAGGLILAYTRSRKLVEAKDEPSQACAEHEWAPGGALTADAEAAAGSQAEGRRQLASEGLPALAQGAERV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Brugada Syndrome and Brugada Syndrome 3

Location

Highly expressed in heart; skeletal muscle; brain; spinal cord and placenta.

DOI ID

10.1006/geno.1999.5904; 10.1101/gr.2596504; 10.1016/s0006-3495(02)73961-1; 10.1002/jcp.22265; 10.1136/jmg.39.5.359; 10.1016/j.amjcard.2005.03.086; 10.1016/j.hrthm.2007.12.019; 10.1161/circep.110.959619

RefSeq

NP_036414.1